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专利名称：Stimulation of osteogenesis using rank
ligand fusion proteins
发明人：Jonathan Lam,F. Patrick Ross,Steven L.
Teitelbaum
申请号：US10105057申请日：20020322
公开号：US20030013651A1公开日：20030116
摘要：A method of enhancing bone formation comprising administering an effectiveamount of 1) an oligomeric complex of one or more of RANKL, a RANKL fusion protein oran analog, derivative or mimic thereof, 2) an osteogenic compound capable of enhancingactivity of one or more intracellular proteins in osteoblasts or osteoblast precursors,wherein said activity is indicative of bone formation, or 3) an osteogenic compoundcapable of inactivating one or more phosphatases in osteoblasts or osteoblast
precursors, wherein said inactivation is indicative of bone formation. The method also maybe used to treat a disease or condition manifested at least in part by the loss of bonemass by administering to a patient a pharmaceutical composition comprising anoligomeric complex or osteogenic compound disclosed herein.
申请人：BARNES-JEWISH HOSPITAL
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