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专利名称：Vectors and methods for gene transfer to
cells
发明人：Wickham, Thomas J., c/o EMD Lexigen
Bedford Campus,Brough, Douglas E.,Kovesdi,Imre
申请号：EP05021223.2申请日：19961127公开号：EP1616961A1公开日：20060118
专利附图：
摘要：The present invention provides a chimeric adenovirus coat protein, which differs
from the wild-type coat protein by the introduction of a nonnative amino acid sequence.Such a chimeric adenovirus coat protein according to the invention is able to direct entryinto cells of a vector comprising the coat protein that is more efficient than entry intocells of a vector that is identical except for comprising a wild-type adenovirus coatprotein rather than the chimeric adenovirus coat protein. The chimeric coat proteinpreferably is a fiber, hexon, or penton protein. The present invention also provides anadenoviral vector that comprises the chimeric adenovirus coat protein, as well asmethods of constructing and using such a vector.
申请人：GENVEC, INC.
地址：12111 Parklawn Drive Rockville, MD 20852 US
国籍：US
代理机构：Hoeger, Stellrecht & Partner Patentanwälte
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